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BioMed Research International
Volume 2013 (2013), Article ID 985259, 11 pages
http://dx.doi.org/10.1155/2013/985259
Research Article

Sonication-Based Improvement of the Physicochemical Properties of Guar Gum as a Potential Substrate for Modified Drug Delivery Systems

1Department of Drug Chemistry and Technologies, University “La Sapienza”, 00185 Rome, Italy
2Department of Sciences and Chemical Technologies, University of Rome “Tor Vergata”, 00133 Rome, Italy
3Magnetic Resonance Laboratory Annalaura Segre, Institute of Chemical Methodologies, CNR Research Area of Rome, Monterotondo Stazione, 00016 Rome, Italy

Received 4 April 2013; Accepted 26 June 2013

Academic Editor: Rares Salomir

Copyright © 2013 Siddique Akber Ansari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Guar Gum is a natural polysaccharide that, due to its physicochemical properties, is extensively investigated for biomedical applications as a matrix for modified drug delivery, but it is also used in the food industry as well as in cosmetics. A commercial sample of Guar Gum was sonicated for different periods of time, and the reduction in the average molecular weight was monitored by means of viscometric measurements. At the same time, the rheological behaviour was also followed, in terms of viscoelasticity range, flow curves, and mechanical spectra. Sonicated samples were used for the preparation of gels in the presence of borate ions. The effect of borax on the new samples was investigated by recording mechanical spectra, flow curves, and visible absorption spectra of complexes with Congo Red. The anisotropic elongation, observed in previous studies with tablets of Guar Gum and borax, was remarkably reduced when the sonicated samples were used for the preparation of the gels.