Table 1: Associations between HLA class I and leprosy.

PopulationStudy designSample sizePhenotypeSerotype, allele, or haplotypeType of associationP or Pc Ref.

EthiopianCase-control20TT, 19LL, 36 controlsTTAw21Susceptibility [7]

Indian Case-control30BT or TT, 40 controlsTTA9Resistance [8]

ThaiCase-control26TT, 183 controlsTTA2
Bw17
Resistance
Susceptibility
  
[9]
Case-control70LL, 183 controlsLLB7Susceptibility

Iran Case-control88LD, 125 controlsLLA1
B35
Resistance
Susceptibility
P < 0.05[10]

Mumbai/IndianCase-control158LL, 150TT, 170 controlsLL
LL
LL
TT/LL
TT/LL
B-40
Aw19
A2-B40
A11-B40
A24-B40
Susceptibility
Resistance
Susceptibility
Susceptibility
Susceptibility
  
  
  
  
[11]

JapaneseCase-control295LL, 74TL, 110 controlsLLB7
Bw54
Susceptibility
Resistance
  
[12]

KoreanCase-control157LD, 162 controlsLDA2
A11
Aw33
Cw5
Resistance
Susceptibility
Susceptibility
Resistance
  
  
  
[13]

IndianCase-control65ENL, 71LLENLA11Susceptibility [14]

IndianCase-control68LL, 237 controlsLLB60Susceptibility
Case-control138LD, 237 controlsLDB60Susceptibility [15]
Case-control20BB, 237 controlsBBB40Susceptibility

Southern ChineseCase-control50LL, 69 controlsLLB46Resistance [16]

TurkishCase-control80LD, 120 controlsLDA9
A10
Bw4
Bw6
Cw1
Cw2
A3
B49
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Resistance
Resistance
  
  
  
  
  
  
  
[17]

Southern IndianCase-control32LD, 67 controlsLDA * 02:06  
A*11:02  
B*51 : 10  
B*18:01  
C*04:07  
C*07:03  
C*04:11
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Resistance
  
  
  
  
  
  
[18]

Mumbai/IndianCase-control103LD, 101 controlsLDA02
A11
A28
B12
B15
B40
Cw7
Cw3
Susceptibility
Susceptibility
Resistance
Resistance
Resistance
Susceptibility
Susceptibility
Resistance
  
  
  
  
  
  
  
[19]
Case-control32ML, 67 controlsMLA * 02:06  
A*11:02  
B*18:01  
B*51:10  
C*04:07  
C*04:11  
C*07:03
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Susceptibility
Resistance
Susceptibility
  
  
  
  
  
  
Case-control32ML, 67 controlsMLA * 11-B * 40 Susceptibility

BrazilianCase-control224LD, 446 controlsLDA * 11  
B*38  
C*12  
C*16
Susceptibility
Susceptibility
Susceptibility
Resistance
  
  
  
[20]
Case-control88LL, 48TTLLC * 07  
B*35  
C*04
Susceptibility
Resistance
Resistance
  
  

Vietnamese family study198 familiesLDC * 15:05 SusceptibilityP = 0.0063
family study292 familiesLDC * 15:05 Susceptibility [21]

IndianCase-control364LD, 371 controlsLDC * 15:05 Susceptibility

MB: multibacillary leprosy; LL: lepromatous leprosy; BB: borderline borderline; TT: tuberculoid leprosy; ENL: erythema nodosum leprosum; LD: leprosy disease; ns: not significant; Pc: corrected Value; Ref.: reference.