Heat Shock Protein 72 Expressing Stress in Sepsis: Unbridgeable Gap between Animal and Human Studies—A Hypothetical “Comparative” Study
Figure 3
(a) Diagram showing summaries of conclusions regarding the Hsp72 protective effects in sepsis in human and animal studies (); (b) human Hsp72 induction methods showed inconsistent results compared to the unanimous Hsp72 protective results in experimental sepsis with any attempted induction method; selection of any induction method, however, did not affect results; (c) Hsp72 induction protective effect using various induction methods was not influenced by the in vitro, in vivo, or combined study method selected: iHsp72, inducible heat shock protein 72; AdHSP, adenoviral vector Hsp72; exogHsp, exogenous Hsp72 preparations; Gln, glutamine; +, additional challenge; HS, heat stress; rHsp72, recombinant Hsp72; Hspgene, Hsp72 gene-transfected models; both, in vitro and in vivo experiments.
