Carvedilol Ameliorates Early Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats

Figure 2

Effect of carvedilol (Carv; 1 and 10 mg/kg/day) on renal malondialdehyde (a), reduced glutathione (b), nitric oxide (as nitrite/nitrate; (c)), and tumor necrosis factor-α (d) levels of streptozotocin-induced early diabetic nephropathy (EDN) in rats. Data are mean ± SEM of 10 rats. a,b,cSignificantly different from control, EDN, and Carv-1 groups, respectively, at 𝑃<0.05.

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