Carvedilol Ameliorates Early Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats
Figure 4
Effect of carvedilol (1 and 10 mg/kg/day) on kidney histopathological picture of streptozotocin-induced early diabetic nephropathy in rats (H&E 40x). (a) Kidney tissue of nondiabetic rat. Notice the normal appearance of the glomerular capillaries (arrow), with both proximal convoluted tubule (PC) and distal convoluted tubule (DC) showing normal epithelium. (b) Kidney tissue of diabetic rat; the glomerular capillaries are widened, irregular, and attached to Bowman’s capsule (arrow). Furthermore, mesangial cell number was relatively higher in diabetic group. Some glomerular capillaries showing nodular sclerosis (arrowhead). Tubular epithelium is also affected (asterisk). (c) Kidney tissue after treatment with 1 mg carvedilol; the histological features are relatively improved compared to nontreated diabetic group. The glomerular capillaries retain their normal size and appearance (arrow), but mesangial cell number is still relatively higher than normal (arrowhead) and tubular epithelium is diminished (asterisk). (d) Kidney tissue from diabetic rat treated with 10 mg carvedilol; the histological features greatly improved and are nearly back to normal structure of glomerular capillaries (arrow) and tubular epithelium (asterisk).
