Carvedilol Ameliorates Early Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats
Figure 6
Transmission electron micrographs of rat renal tissue. (a) Kidney tissue of nondiabetic rat. Notice normal thickness and appearance of glomerular basement membrane (red arrows) and podocyte foot processes (asterisks). (b) Kidney tissue of diabetic rat showing thick and wrinkled glomerular basement membrane (red arrows). Effacement of podocyte foot processes (blue arrow). (c) Kidney tissue after treatment with 1 mg carvedilol. Notice little improvement in the thickness and course of the glomerular basement membrane (red arrows). Effacement of podocyte foot processes (blue arrows). (d) Kidney tissue from diabetic rat treated with 10 mg carvedilol; notice that the glomerular basement membrane is nearly of normal thickness and course (red arrows) and normal podocyte foot processes (asterisk) minimum effacement could be observed (blue arrow).
