The Evolving Role of Radiosurgery in the Management of Radiation-Induced Meningiomas: A Review of Current Advances and Future Directions

Table 1

Series of radiation-induced meningiomas treated by stereotactic radiosurgery.

Author and year

𝑁

Original diagnosis for RT

Mean age (yrs.)*

F/M

Mean RT dose (Gy)

Mean latency (yrs.)

Mean SRS dose (Gy)

Mean tumor volume (cm^3)

WHO grade

Mean follow-up (yrs.)

Morbidity

Tumor progression

Jensen et al., 2005 [14]

16

3, pituitary tumor; 3, astrocytoma; 2, tumor NOS; 1, oligodendroglioma; 1, tinea capitis; 1, craniopharyngioma; 1, neuroblastoma; 1, ALL; 1, glioma; 1, esthesioneuroblastoma; 1, spindle cell tumor

47.5

10/6

55.6 (𝑛=12)

32.3

margin, 15.9

10.0

—

3.4

1 (6.3%); −1, increased seizure activity

1/19; (5.3%)

Kondziolka et al., 2009 [6]

19

4, pituitary adenoma; 3, medulloblastoma; 2, leukemia; 2, astrocytoma; 1, pilocytic astrocytoma; 1, oligodendroglioma; 1, craniopharyngioma; 1, retinoblastoma; 1 rhabdomyosarcoma; 1, scalp hemangioma; 1, pineal mass; 1, experimental

39.5

10/9

42.8 (𝑛=5)

29.7

margin, 12.9; maximum, 26.2

7.6

5, gr. I; 2, gr. II; 12, N/A

3.4

1 (5.3%); −1, optic neuropathy

6/24; (25%)

Kuhn et al., 2012 [15]

12

1, epidermoid carcinoma; 2, astrocytoma; 1, medulloblastoma; 1, tinea capitis; 1, lymphoma; 1, scalp hemangioma; 1, oligodendroglioma; 1, neuroblastoma; 1, ependymoma; 1, pituitary tumor; 1, pilocytic astrocytoma

53.1

7/5

52.9 (𝑛=3)

34.8

margin, 13.6

1.7

2, gr. I; 4, gr. II; 6, N/A

2.5

2 (16.7%); −1, CN V, VII, and VIII neuropathy; −1, left leg weakness and numbness

2/24; (8.3%)

∗Age at diagnosis of radiation-induced meningioma.
ALL: acute lymphoblastic leukemia; N/A: not available; NOS: not otherwise specified; RT: radiation therapy.