The Evolving Role of Radiosurgery in the Management of Radiation-Induced Meningiomas: A Review of Current Advances and Future Directions

Table 2

Select series of surgically treated radiation-induced meningiomas.

Author and year	𝑁	Original diagnosis for RT	Mean age (yrs.)*	F/M	Mean RT dose (Gy)	Mean latency (yrs.)	Histology	WHO grade	Mean follow-up (yrs.)	Recurrence
Harrison et al., 1991 [5]	7	2, tinea capitis; 1, presumed sarcoma; 1. prepubertal gigantism; 1, thalamic glioma; 1, keloid; 1, astrocytoma	53.4	5/2	—	42.7	3, atypical; 2, meningothelial; 1, transitional; 1, mixed (meningothelial, transitional, fibroblastic)	—	—	3 (42.9%)
Salvati et al., 1996 [29]	10	4, ALL; 2, medulloblastoma; 2, adenoma; 1, carcinoma; 1, astrocytoma	30.4	7/3	39.8	16.9	4, atypical; 4, fibroblastic; 1, meningothelial; 1, transitional	—	—	1 (10%)
Sadetzki et al., 2002 [30]	253^†	253, tinea capitis	43.6	1.9 : 1	—	36.3	183, NOS; 63, meningothelial; 38, transitional; 31, fibroblastic; 4, angioblastic; 2, psammomatous; 1, malignant; 6, mixed	—	9.8	18.2%
De Tommasi et al., 2005 [31]	6	6, tinea capitis	57.7	4/2	15	40.2	2, meningothelial; 2, transitional; 1, choroid; 1 atypical	4, I; 2, II	—	0
Banerjee et al., 2009 [32]	8	8, ALL	26.5	5/3	26.5	23	3, meningothelial; 2, fibroblastic; 2, transitional; 1, atypical	7, I; 1, II	—	2 (25%)
Godlewski et al., 2012 [33]	19	4, ALL; 3, NHL; 3, astrocytoma; 2, ependymoma; 1, pituitary adenoma; 1, medulloblastoma; 1, “brain tumor”; 1, CNS lymphoma; 1, leukemia; 1, germinoma; 1, ganglioneuroblastoma	35.7	12/7	31.9	25.9	—	17, I; 1, II; 1, N/A	5.8	4 (21.1%)

∗Age at diagnosis of radiation-induced meningioma.
†220/253 patients were treated by surgical resection.
ALL: acute lymphoblastic leukemia; N/A: not available; NHL: non-Hodgkin’s lymphoma; NOS: not otherwise specified; RT: radiation therapy.