Conditioned Media from Human Adipose Tissue-Derived Mesenchymal Stem Cells and Umbilical Cord-Derived Mesenchymal Stem Cells Efficiently Induced the Apoptosis and Differentiation in Human Glioma Cell Lines In Vitro

Figure 6

MSCs conditioned media coculture leads to significant differentiation of U251 cells towards a normal glial cell phenotype. Phase contrast image of U251 cells before and after MSCs conditioned media coculture. U251 glioma cells are usually with short processes. Much more and longer processes were seen after MSCs conditioned media induction and these processes connected with neighboring cells, forming an interconnected network.