|
Author;
year | Tumor cell line | Control group | Methods | NTPDase5 expression | mt-PCPH expression |
|
|
Beckenkamp et al., 2014 [14] | Cervical cancer cell lines SiHa, HeLa, and C33A | Normal immortalized keratinocytes (HaCaT cells) | RT-PCR | Expressed in all cell lines with higher levels in SiHa cells than HeLa, C33A, and HaCaT cells | Not described |
| Zadran et al., 2012 [15] | Human brain tumor cell lines U87 and U87vIII | Not described | WB | Expressed in U87 and at higher levels in U87vIII | Not described |
| Villar et al., 2007 [16] | Human prostate tumor cells lines LNCaP, C42, and PC3 | Nonneoplastic human prostatic epithelial cells (RWPE-1) | RT-PCR and WB | Not detected in RWPE-1 but it was highly detected in LNCaP and in both C42 and PC3 was expressed at lower levels | Not described |
|
Regadera et al., 2006 [17] | Testicular germ cell tumors NCCIT (mutant Tp53) and NT2/D1 (wild-type Tp53) | Not described | WB | Both cell lines expressed several NTPDase5-immunorelated polypeptides (ranged 20–90 KDa) | Low molecular-size polypeptides were less abundant in NT2/D1 than NCCIT cells |
| Blánquez et al., 2004 [18] | Human benign and malignant neoplastic breast samples | Normal human breast tissue samples | WB | Both normal tissue and benign and malignant breast tumors samples showed the expression of the NTPDase5 protein | Only the more aggressive breast tumor samples expressed the mt-PCPH |
| Blánquez et al., 2002 [19] | Cell lines cultured from explants of laryngeal tumors (SCC) at stages II, III, and IV | Primary laryngeal epithelial cells (LECs) from the normal margin of surgical specimens | WB | Expression related directly to the evolution of the three grades of laryngeal dysplasia, characterized by increments of cell proliferation in parallel with changes in epithelial differentiation | LECs expressed more mt-PCPH than normal NTPDase5 and SCCs presented a loss in the mt-NTPDase5 |
|
Rouzaut et al., 2001 [12] | 20 mammary tumor derived cell lines | Not described | WB | Detectable in 8 of the 20 cells lines | The mt-PCPH, after prolonged exposures, was detectable in all but two cell lines |
|
Rouzaut et al., 2001 [12] | 18 tumor cell lines derived from the central or peripheral nervous system | Not described | WB | Absent in 13 cell lines and barely detectable in 4 cell lines | Expressed in 13 cell lines |
|
Rouzaut et al., 2001 [12] | 6 colon tumor cell lines | Not described | WB | Expressed highly in all six cell lines | Expressed in 4 cell lines |
|
Rouzaut et al., 2001 [12] | 5 lung tumor cell lines | Not described | WB | Detectable at low levels in all five cell lines | Detectable at low levels in 4 cell lines |
|
Rouzaut et al., 2001 [12] | 1 pancreas tumor cell line | Not described | WB | Highly expressed | Detectable at low levels |
|
