Ligation Strategies for Targeting Liposomal Nanocarriers

<table>Bioorthogonal chemistry approaches for coupling ligands. Schematic representation of a cross section of a liposome bilayer containing functional groups to illustrate: (a) and (b) copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (CuAAC) ligation, (c) copper-free click chemistry ligation, (d) the Staudinger ligation, and (e) tetrazine/<i>trans</i>-cyclooctene inverse electron demand Diels-Alder cycloaddition (IEDDA). Coupling ligands are represented by a red star.</table>

BioMed Research International

fig3

Figure 3

Figure 3: Ligation Strategies for Targeting Liposomal Nanocarriers 