Research Article

Essential Functional Modules for Pathogenic and Defensive Mechanisms in Candida albicans Infections

Table 2

Enriched functional modules for defensive mechanisms in zebrafish and the corresponding significant proteins shown in Figure 4 during the host-pathogen interaction.

Functional moduleProtein symbol

Immune responseTlr2, B2m, Akt2, Akt2l, Apaf1, Cxcr3.2, Pik3r3a, Sigirr, Ticam1, Tlr20a, Vtna

Apoptosis mechanismAkt2, Akt2l, Apaf1, Cdk5, Gdnfa, Nras, Phlda3, Pik3r3a, Plcg2, Prkar2ab, Sgk1, Tax1bp1a

Ion transportTfa, Abcc9, Cacnb3a, Cacnb4b, Clk2a, Cox5ab, Grid2, Grin1a, Grin1b, Kcnh1, Kcnq1, Sfxn1, si:ch211-12e13.7, si:ch211-258f14.5, Slc12a3, Slc26a6l, Slc39a6, Trpc6a, Trpm7, zgc:109934, zgc:162160

Protein secretionRab2a, Rab3da, Rab3db, Rab6ba, Rab8a, Rab10, Rab11a, Rab35, Ap1m2, Ap3m1, Atg4c, Bcap31, Naca, Nup85, Ramp2, Scamp2, Snx17, Tnpo2, Trpc4apa, zgc:113338

Hemostasis-related processesCalcrla, Lama4, Acvrl1, Bmp4, Cdh2, Csrp1a, Ell, Gata2a, Hapln1b, Hopx, Nr2f2, Nrxn3a, Nrxn3b, Plxnb2a, Rab11a

The table lists five of the functional modules considered to be essential in the C. albicans-zebrafish interaction and the corresponding proteins with associated GO annotation.