About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2014 (2014), Article ID 137304, 10 pages
http://dx.doi.org/10.1155/2014/137304
Research Article

Guideline Concordant Therapy Prolongs Survival in HER2-Positive Breast Cancer Patients: Results from a Large Population-Based Cohort of a Cancer Registry

1Department of Gynecology and Obstetrics, University Medical Center Regensburg, Landshuter Straße 65, 93053 Regensburg, Germany
2Center for Clinical Studies, University Hospital Regensburg, 93053 Regensburg, Germany
3Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany
4Tumor Center Regensburg e.V., University of Regensburg, 93053 Regensburg, Germany

Received 10 January 2014; Accepted 6 February 2014; Published 20 March 2014

Academic Editor: Peter A. Fasching

Copyright © 2014 E. C. Inwald et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. J. Slamon, G. M. Clark, S. G. Wong, W. J. Levin, A. Ullrich, and W. L. McGuire, “Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene,” Science, vol. 235, no. 4785, pp. 177–182, 1987. View at Scopus
  2. H. Tsuda, “Prognostic and predictive value of c-erbB-2 (HER-2/neu) gene amplification in human breast cancer,” Breast Cancer, vol. 8, no. 1, pp. 38–44, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. S. A. Hurvitz, Y. Hu, N. O'Brien, and R. S. Finn, “Current approaches and future directions in the treatment of HER2-positive breast cancer,” Cancer Treatment Reviews, vol. 39, no. 3, pp. 229–219, 2013. View at Publisher · View at Google Scholar
  4. D. J. Slamon, B. Leyland-Jones, S. Shak et al., “Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2,” The New England Journal of Medicine, vol. 344, no. 11, pp. 783–792, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. E. A. Eisenhauer, “From the molecule to the clinic—inhibiting HER2 to treat breast cancer,” The New England Journal of Medicine, vol. 344, no. 11, pp. 841–842, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. M. A. Cobleigh, C. L. Vogel, D. Tripathy et al., “Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease,” Journal of Clinical Oncology, vol. 17, no. 9, pp. 2639–2648, 1999. View at Scopus
  7. M. Marty, F. Cognetti, D. Maraninchi et al., “Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group,” Journal of Clinical Oncology, vol. 23, no. 19, pp. 4265–4274, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Gasparini, M. Gion, L. Mariani et al., “Randomized phase II trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first-line therapy of patients with Her-2 positive advanced breast cancer,” Breast Cancer Research and Treatment, vol. 101, no. 3, pp. 355–365, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. T. L. Brenner and V. R. Adams, “First MAb approved for treatment of metastatic breast cancer,” Journal of the American Pharmaceutical Association, vol. 39, no. 2, pp. 236–238, 1999. View at Scopus
  10. M. J. Piccart-Gebhart, M. Procter, B. Leyland-Jones et al., “Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer,” The New England Journal of Medicine, vol. 353, no. 16, pp. 1659–1672, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. I. Smith, M. Procter, R. D. Gelber et al., “2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial,” The Lancet, vol. 369, no. 9555, pp. 29–36, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Joensuu, P.-L. Kellokumpu-Lehtinen, P. Bono et al., “Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer,” The New England Journal of Medicine, vol. 354, no. 8, pp. 809–820, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. E. H. Romond, E. A. Perez, J. Bryant et al., “Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer,” The New England Journal of Medicine, vol. 353, no. 16, pp. 1673–1684, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Slamon, W. Eiermann, N. Robert et al., “Adjuvant trastuzumab in HER2-positive breast cancer,” The New England journal of medicine, vol. 365, no. 14, pp. 1273–1283, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Spielmann, H. Roché, T. Delozier et al., “Trastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCC-PACS 04 trial,” Journal of Clinical Oncology, vol. 27, no. 36, pp. 6129–6134, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Slamon, W. Eiermann, N. Robert et al., “BCIRG 006: 2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC→T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC→TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients,” Breast Cancer Research and Treatment, vol. 100, supplement 1, 2006.
  17. M. Harris, “Monoclonal antibodies as therapeutic agents for cancer,” The Lancet Oncology, vol. 5, no. 5, pp. 292–302, 2004. View at Publisher · View at Google Scholar
  18. G. A. Viani, S. L. Afonso, E. J. Stefano, L. I. de Fendi, and F. V. Soares, “Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials,” BMC Cancer, vol. 7, article 153, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. G. Fried, T. Regev, and M. Moskovitz, “Trastuzumab-related cardiac events in the treatment of early breast cancer,” Breast Cancer Research and Treatment, vol. 142, no. 1, pp. 1–7, 2013. View at Publisher · View at Google Scholar
  20. G. E. Konecny, “Emerging strategies for the dual inhibition of HER2-positive breast cancer,” Current Opinion in Obstetrics & Gynecology, vol. 25, no. 1, pp. 55–65, 2013. View at Publisher · View at Google Scholar
  21. C. Melcher, C. Scholz, B. Jäger, C. Hagenbeck, B. Rack, and W. Janni, “Breast cancer: state of the art and new findings,” Geburtsh Frauenheilk, vol. 72, no. 3, pp. 215–224, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Lüftner, M. Lux, N. Maass et al., “Advances in breast cancer—looking back over the year,” Geburtsh Frauenheilk, vol. 72, no. 12, pp. 1117–1129, 2012. View at Publisher · View at Google Scholar
  23. M. Hubalek, C. Brantner, and C. Marth, “Role of pertuzumab in the treatment of HER2-positive breast cancer,” Breast Cancer: Targets and Therapy, vol. 2012, pp. 65–73, 2012. View at Publisher · View at Google Scholar
  24. H. Kolberg, D. Lüftner, M. Lux et al., “Breast cancer 2012—new aspects,” Geburtsh Frauenheilk, vol. 72, no. 7, pp. 602–615, 2012. View at Publisher · View at Google Scholar
  25. I. Vaz-Luis, R. A. Ottesen, M. E. Hughes et al., “Impact of hormone receptor status on patterns of recurrence and clinical outcomes among patients with human epidermal growth factor-2-positive breast cancer in the National Comprehensive Cancer Network: a prospective cohort study,” Breast Cancer Research, vol. 14, no. 5, article R129, 2012. View at Publisher · View at Google Scholar
  26. C. Palmieri, D. Shah, J. Krell et al., “Management and outcome of HER2-positive early breast cancer treated with or without trastuzumab in the adjuvant trastuzumab era,” Clinical Breast Cancer, vol. 11, no. 2, pp. 93–102, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Dawood, K. Broglio, A. U. Buzdar, G. N. Hortobagyi, and S. H. Giordano, “Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: an institutional-based review,” Journal of Clinical Oncology, vol. 28, no. 1, pp. 92–98, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. M. D. Seal, C. H. Speers, S. O'Reilly, K. A. Gelmon, S. L. Ellard, and S. K. Chia, “Outcomes of women with early-stage breast cancer receiving adjuvant trastuzumab,” Current Oncology, vol. 19, no. 4, pp. 197–201, 2012. View at Publisher · View at Google Scholar
  29. M. Campiglio, R. Bufalino, M. Sasso et al., “Effect of adjuvant trastuzumab treatment in conventional clinical setting: an observational retrospective multicenter Italian study,” Breast Cancer Research and Treatment, vol. 141, no. 1, pp. 101–110, 2013. View at Publisher · View at Google Scholar
  30. J. M. Grimshaw and I. T. Russell, “Effect of clinical guidelines on medical practice: a systematic review of rigorous evaluations,” The Lancet, vol. 342, no. 8883, pp. 1317–1322, 1993. View at Publisher · View at Google Scholar · View at Scopus
  31. R. Kreienberg, I. Kopp, U. Albert et al., Interdisciplinary S3 Guideline for Diagnosis and Therapy of Breast Cancer in Women, German Cancer Society, Berlin, Germany, 2008.
  32. R. Kreienberg, U. Albert, M. Follmann, I. Kopp, T. Kühn, and A. Wöckel, “Interdisciplinary GoR level III guidelines for the diagnosis, therapy and follow-up care of breast cancer,” Geburtsh Frauenheilk, vol. 73, no. 6, pp. 556–583, 2013. View at Publisher · View at Google Scholar
  33. A. C. Wolff, M. E. H. Hammond, J. N. Schwartz et al., “American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer,” Journal of Clinical Oncology, vol. 25, no. 1, pp. 118–145, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. E. C. Inwald, M. Klinkhammer-Schalke, F. Hofstädter et al., “Ki-67 is a prognostic parameter in breast cancer patients: results of a large population-based cohort of a cancer registry,” Breast Cancer Research and Treatment, vol. 139, no. 2, pp. 539–552, 2013. View at Publisher · View at Google Scholar
  35. N. Eisemann, A. Waldmann, and A. Katalinic, “Epidemiology of breast cancer—current figures and trends,” Geburtsh Frauenheilk, vol. 73, no. 2, pp. 130–135, 2013. View at Publisher · View at Google Scholar
  36. A. C. Wolff, M. E. H. Hammond, D. G. Hicks et al., “Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update,” Journal of Clinical Oncology, vol. 31, no. 31, pp. 3997–4013, 2013. View at Publisher · View at Google Scholar
  37. L. C. Tong, N. Nelson, J. Tsourigiannis, and A. M. Mulligan, “The effect of prolonged fixation on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast cancer: a prospective study,” The American Journal of Surgical Pathology, vol. 35, no. 4, pp. 545–552, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Ferrero-Poüs, K. Hacène, C. Bouchet, V. le Doussal, M. Tubiana-Hulin, and F. Spyratos, “Relationship between c-erbB-2 and other tumor characteristics in breast cancer prognosis,” Clinical Cancer Research, vol. 6, no. 12, pp. 4745–4754, 2000. View at Scopus
  39. S. Ménard, A. Balsari, E. Tagliabue et al., “Biology, prognosis and response to therapy of breast carcinomas according to HER2 score,” Annals of Oncology, vol. 19, no. 10, pp. 1706–1712, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Konecny, G. Pauletti, M. Pegram et al., “Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer,” Journal of the National Cancer Institute, vol. 95, no. 2, pp. 142–153, 2003. View at Scopus
  41. S. Goel, J. Chirgwin, P. Francis et al., “Rational use of trastuzumab in metastatic and locally advanced breast cancer: implications of recent research,” Breast, vol. 20, no. 2, pp. 101–110, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Schmidt, P. Fasching, M. Beckmann, and H. Kölbl, “Biomarkers in breast cancer—an update,” Geburtsh Frauenheilk, vol. 72, no. 9, pp. 819–832, 2012. View at Publisher · View at Google Scholar
  43. A. Wöckel, C. Kurzeder, V. Geyer et al., “Effects of guideline adherence in primary breast cancer—a 5-year multi-center cohort study of 3976 patients,” The Breast, vol. 19, no. 2, pp. 120–127, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. M. E. Hamaker, W. H. Schreurs, J. M. Uppelschoten, and C. H. Smorenburg, “Breast cancer in the elderly: retrospective study on diagnosis and treatment according to national guidelines,” The Breast Journal, vol. 15, no. 1, pp. 26–33, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. N. Hébert-Croteau, J. Brisson, J. Latreille, M. Rivard, N. Abdelaziz, and G. Martin, “Compliance with consensus recommendations for systemic therapy is associated with improved survival of women with node-negative breast cancer,” Journal of Clinical Oncology, vol. 22, no. 18, pp. 3685–3693, 2004. View at Publisher · View at Google Scholar · View at Scopus
  46. K. Hancke, M. D. Denkinger, J. König et al., “Standard treatment of female patients with breast cancer decreases substantially for women aged 70 years and older: a German clinical cohort study,” Annals of Oncology, vol. 21, no. 4, pp. 748–753, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. L. Schwentner, R. Wolters, M. Wischnewsky, R. Kreienberg, and A. Wöckel, “Survival of patients with bilateral versus unilateral breast cancer and impact of guideline adherent adjuvant treatment: a multi-centre cohort study of 5292 patients,” The Breast, vol. 21, no. 2, pp. 171–177, 2012. View at Publisher · View at Google Scholar · View at Scopus
  48. L. Schwentner, R. van Ewijk, C. Kurzeder et al., “Participation in adjuvant clinical breast cancer trials: does study participation improve survival compared to guideline adherent adjuvant treatment? A retrospective multi-centre cohort study of 9, 433 patients,” European Journal of Cancer, vol. 49, no. 3, pp. 553–563, 2013. View at Publisher · View at Google Scholar
  49. W. van de Water, E. Bastiaannet, O. M. Dekkers et al., “Adherence to treatment guidelines and survival in patients with early-stage breast cancer by age at diagnosis,” British Journal of Surgery, vol. 99, no. 6, pp. 813–820, 2012. View at Publisher · View at Google Scholar · View at Scopus
  50. C. R. Friese, T. M. Pini, Y. Li et al., “Adjuvant endocrine therapy initiation and persistence in a diverse sample of patients with breast cancer,” Breast Cancer Research and Treatment, vol. 138, no. 3, pp. 931–939, 2013. View at Publisher · View at Google Scholar
  51. L. Schwentner, A. Wockel, J. Konig et al., “Adherence to treatment guidelines and survival in triple-negative breast cancer: a retrospective multi-center cohort study with 9156 patients,” BMC Cancer, vol. 13, no. 1, article 487, 2013. View at Publisher · View at Google Scholar
  52. S. B. Yellen, D. F. Cella, and W. T. Leslie, “Age and clinical decision making in oncology patients,” Journal of the National Cancer Institute, vol. 86, no. 23, pp. 1766–1770, 1994. View at Scopus
  53. L. Gianni, U. Dafni, R. D. Gelber et al., “Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial,” The Lancet Oncology, vol. 12, no. 3, pp. 236–244, 2011. View at Publisher · View at Google Scholar · View at Scopus
  54. H. Joensuu, P. Bono, V. Kataja et al., “Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer trial,” Journal of Clinical Oncology, vol. 27, no. 34, pp. 5685–5692, 2009. View at Publisher · View at Google Scholar · View at Scopus
  55. A. Templeton, A. Ocaña, B. Šeruga et al., “Management of small HER2 overexpressing tumours,” Breast Cancer Research and Treatment, vol. 136, no. 1, pp. 289–293, 2012. View at Publisher · View at Google Scholar
  56. P. S. Craft, J. M. Buckingham, J. E. Dahlstrom et al., “Variation in the management of early breast cancer in rural and metropolitan centres: implications for the organisation of rural cancer services,” The Breast, vol. 19, no. 5, pp. 396–401, 2010. View at Publisher · View at Google Scholar · View at Scopus
  57. S. Houterman, M. L. G. Janssen-Heijnen, C. D. G. W. Verheij et al., “Comorbidity has negligible impact on treatment and complications but influences survival in breast cancer patients,” British Journal of Cancer, vol. 90, no. 12, pp. 2332–2337, 2004. View at Scopus
  58. W. J. Louwman, M. L. G. Janssen-Heijnen, S. Houterman et al., “Less extensive treatment and inferior prognosis for breast cancer patient with comorbidity: a population-based study,” European Journal of Cancer, vol. 41, no. 5, pp. 779–785, 2005. View at Publisher · View at Google Scholar · View at Scopus