Performance of Quantification of Modified Hodge Test: An Evaluation with Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Isolates

Table 1

Minimal inhibitory concentration (MIC) of carbapenems of the 384 isolates evaluated.

Isolates	𝑛					MIC (mg/L)^a
		Imipenem				Meropenem				Ertapenem
		MIC^b	MIC50	MIC90	Range	MIC^b	MIC50	MIC90	Range	MIC^b	MIC50	MIC90	Range
KPC-producing isolates	50	—	16	128	1.0–256	—	32	128	4.0–>256	—	64	256	4.0–>256
Klebsiella spp.	36	—	16	64		—	32	64		—	64	128
Enterobacter spp.	10	—	8	64		—	16	128		—	32	256
S. marcescens	3	—	128	256		—	32	64		—	64	128
K. georgiana	1	256	—	—		128	—	—		128	—	—
Non-carbapenemase-producing isolates	334	—	0.5	2.0	≤0.5–32		0.5	4.0	≤0.5–32		4.0	16	≤0.5–128
Enterobacter spp.	220	—	0.5	2.0			0.5	2.0			4.0	8.0
Klebsiella spp.	89	—	1.0	4.0			1.0	8			4.0	32
E. coli	17	—	0.5	4.0			1.0	4.0			4.0	16
S. marcescens	5	—	1.0	4.0			1.0	4.0			2.0	8.0
P. mirabilis	1	2.0	—	—		0.5	—	—		0.5	—	—
M. morganii	1	4.0	—	—		0.5	—	—		0.5	—	—
C. freundii	1	≤0.5	—	—		0.5	—	—		0.5	—	—

aDetermined by broth microdilution [17].
^bResult of MIC of species with a single isolate.