Review Article
Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes
Table 2
The serum biomarker levels in Sod1−/− mice.
| Markers | Concentrations | Sod1+/+ | Sod1−/− | value |
| IL-10 | ng/mL | 425 ± 54 | 451 ± 60 | 0.495 | IL-11 | pg/mL | 39 ± 14.4 | 33 ± 13.2 | 0.627 | IL-12p70 | ng/mL | ND | ND | — | IL-17 | pg/mL | ND | ND | — | IL-18 | ng/mL | 10 ± 1.1 | 12 ± 1.21 | 0.105 | IL-1alpha | pg/mL | 83 ± 63 | 134 ± 89.4 | 0.467 | IL-1beta | ng/mL | 12 ± 1.1 | 13 ± 1.6 | 0.268 | IL-2 | pg/mL | ND | ND | — | IL-3 | pg/mL | ND | ND | — | IL-4 | pg/mL | 20.2 ± 0.0 | 20.2 ± 0.0 | 1 | IL-5 | ng/mL | 0.23 ± 0.066 | 0.19 ± 0.055 | 0.406 | IL-6 | pg/mL | 4.4 ± 1.7 | 18 ± 14.3 | 0.102 | IL-7 | ng/mL | 0.02 ± 0.016 | 0.05 ± 0.025 | 0.296 | IP-10 | pg/mL | 99 ± 17.1 | 150 ± 60.3 | 0.109 | M-CSF | pg/mL | 6.9 ± 0.50 | 6.0 ± 0.25 | 0.010* | MCP-1 | pg/mL | 100 ± 34.2 | 124 ± 60.0 | 0.457 | MCP-3 | pg/mL | 235 ± 50.9 | 235 ± 69.3 | 0.996 | MCP-5 | pg/mL | 18 ± 1.7 | 24 ± 7.0 | 0.094 | MIP-1alpha | ng/mL | 1.6 ± 0.21 | 1.7 ± 0.09 | 0.307 | MIP-1beta | pg/mL | 55 ± 16.5 | 80 ± 17.5 | 0.005* | MIP-1gamma | pg/mL | 26 ± 3.6 | 34 ± 3.7 | 0.013* | MIP-2 | pg/mL | 18 ± 2.1 | 20 ± 5.2 | 0.371 | MIP-3beta | ng/mL | 1.8 ± 0.37 | 1.7 ± 0.14 | 0.349 | MDC | pg/mL | 547 ± 234 | 626 ± 42 | 0.481 | RANTES | pg/mL | 0.26 ± 0.130 | 0.45 ± 0.049 | 0.014* | TNF-alpha | ng/mL | 0.066 ± 0.004 | 0.077 ± 0.010 | 0.041* | TPO | ng/mL | 75 ± 9.4 | 86.5 ± 5.6 | 0.049* |
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ND indicates “not detected”. indicates a significant difference.
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