141396.fig.001a
(a) Stress
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(b) MDMA
Figure 1: Gene expression changes following exposure to stress and MDMA. (a) Relative number of genes induced or suppressed by stress in the hippocampus of rats subsequently treated with saline or MDMA. Boxes outlined above the horizontal line indicate genes induced by stress and boxes outlined below the horizontal line indicate the number of genes suppressed by stress. Boxes outlined to the left and right of the vertical line indicated the number of genes up- or downregulated by saline or MDMA treatment, respectively. The shaded boxes in the middle of the diagram indicate the number of genes induced or suppressed by stress that were identical in saline and MDMA-treated animals and are considered MDMA-resistant. (b) Relative number of genes induced or suppressed by MDMA in the rat hippocampus of rats previously exposed to no stress or chronic unpredictable stress.