Review Article
An Overview of the Spindle Assembly Checkpoint Status in Oral Cancer
Table 1
Expression levels of core spindle assembly checkpoint components in oral squamous cell carcinoma.
| SAC protein | Samples | Expression levels | References |
| Cdc20 | OSCC cell lines (7 out of 10) Primary HNSCC (7 out of 10 cases) | Overexpression | [58] | OSCC cell lines (2 of 7) | Overexpression | [59] | OSCC (37 out of 65 cases) | Overexpression | [61] |
| Mad2 | OSCC cell lines (7 out of 7) | Underexpression | [59] |
|
BubR1 | OSCC (43 out of 43 cases) Oral PMD (75 out of 77 cases) | Overexpression | [62] | OSCCIS (15 out of 20 cases) OSCCWT (19 out of 27 cases) OSCCW (18 out of 23 cases) Cervical LN (15 out of 23 cases) |
Overexpression |
[63] | OLNM (16 out of 16 cases) | Underexpression | OSCC (11 out of 49 cases) | Overexpression | [64] |
| Aurora B | OSCC cell lines (7 out of 7) OSCC (71 out of 101) | Overexpression | [66] | OSCC (40 out of 40 cases) | Overexpression | [67] | OSCC (162 out of 215 cases) | Overexpression | [68] |
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PMD: potentially malignant disorders; OSCCIS: in situ OSCC; OSCCWT: invasive OSCC without metastasis; OSCCW: invasive OSCC with metastasis; cervical LN: lymph nodes; OLNM: nonmalignant oral lesions.
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