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References | Sample type | Clinical parameters | miRs deregulated | miRs selected as candidate biomarkers |
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Taylor et al. (2010) [24] | 113 PCa tissues 28 normal tissues | Large screening study | Taylor et al. 10.1016/j.ccr.2010.05.026 |
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Martens-Uzunova et al. (2012) [44] | 102 PCa tissues and normal adjacent tissues | High risk biochemical recurrence | 12 upregulated 13 downregulated | miR-19a, miR-130a, miR-20a/106/93 | ↑ |
miR-27, miR-143, miR-221/222 | ↓ |
|
Tong et al. (2009) [53] |
40 FFPE prostatectomy Specimens (20 without early BCR 20 with early BCR) | Biochemical recurrence | 2 upregulated 4 downregulated | miR-135, miR-194 (40% of case) | ↑ |
miR-145, miR-221, miR-222 | ↓ |
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Schaefer et al. (2010) [54] | 76 PCa and adjacent normal tissues | Biochemical recurrence | 5 upregulated 10 downregulated | miR-96 | ↑ |
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Hulf et al. (2013) [55] | 149 PCa and 30 matched normal tissues | Biochemical recurrence | 1 downregulated | miR-205 | ↓ |
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Schubert et al. (2013) [62] | BCR tissues and disease-free tissues | Biochemical recurrence | 2 downregulated | let-7b and let-7c | ↓ |
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Leite et al. (2011) [66] | 21 frozen BCR tissues 28 frozen disease-free tissues | Biochemical recurrence | 4 upregulated | miR-100 | ↑ |
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Karatas et al. (2014) [72] | 82 PCa tissues (41 BCR and 41 disease-free) | Biochemical recurrence | 3 downregulated | miR-1, miR-133b | ↓ |
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Selth et al. (2013) [102] | Serum samples from PCa patients (BCR = 8) disease-free = 8) | Biochemical recurrence | 3 upregulated | miR-194 miR-146-3p | ↑ |
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Shen et al. (2012) [87] | Plasma samples from PCa () | Castration resistance | 2 upregulated | miR-21, miR-145 | ↑ |
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Jalava et al. (2012) [90] | 28 primary PCa tissues 14 CRPC tissues 12 BPH tissues | Castration resistance | 4 upregulated 3 downregulated | miR-32, miR-148a, miR-590-5p, miR-21 | ↑ |
miR-99a, miR-99b, miR-221 | ↓ |
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Peng et al. (2011) [94] | 6 primary PCa tissues 7 bone metastatic tissues | Metastasis | 5 downregulated | miR-508-5p, miR-143, miR-145, miR-33a, miR-100 | ↓ |
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Saini et al. (2011) [95] | 36 PCa tissues 8 metastatic tissues 8 normal tissues | Metastasis | 1 downregulated | miR-203 | ↓ |
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Mitchell et al. (2008) [19] | Serum samples from metastatic PCa () and age-matched HD () | Metastasis | 6 deregulated | miR-141 | ↑ |
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Brase et al. (2011) [100] | Serum samples from localized PCa () and metastatic PCa () | Metastasis | 5 upregulated | miR-141, miR-375 | ↑ |
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Bryant et al. (2012) [48] | Serum samples from PCa () and metastatic PCa () Plasma samples from PCa () and metastatic PCa () | Metastasis | 2 upregulated | miR-141 and miR-375 | ↑ |
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Nguyen et al. (2013) [103] |
Serum samples from localized PCa () and metastatic CRPC () | Castration resistance | 3 upregulated 1 downregulated | miR-141, miR-375, miR-378* | ↑ |
miR-409-3p | ↓ |
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Zhang et al. (2011) [88] | Serum samples from localized PCa (), ADPC (), CRPC DTX treated () and BPH () | Castration resistance | 1 upregulated | miR-21 | ↑ |
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