|
| References | Sample type | Clinical parameters | miRs deregulated | miRs selected as candidate biomarkers |
|
| Taylor et al. (2010) [24] | 113 PCa tissues
28 normal tissues | Large screening study | Taylor et al. 10.1016/j.ccr.2010.05.026 |
|
|
Martens-Uzunova et al. (2012) [44] | 102 PCa tissues and normal adjacent tissues | High risk biochemical recurrence | 12 upregulated
13 downregulated | miR-19a, miR-130a,
miR-20a/106/93 | ↑ |
miR-27, miR-143,
miR-221/222 | ↓ |
|
|
Tong et al. (2009) [53] |
40 FFPE prostatectomy
Specimens
(20 without early BCR 20 with early BCR) | Biochemical recurrence | 2 upregulated
4 downregulated | miR-135, miR-194
(40% of case) | ↑ |
miR-145, miR-221,
miR-222 | ↓ |
|
| Schaefer et al. (2010) [54] | 76 PCa and adjacent normal tissues | Biochemical recurrence | 5 upregulated
10 downregulated | miR-96 | ↑ |
|
| Hulf et al. (2013) [55] | 149 PCa and 30 matched normal tissues | Biochemical recurrence | 1 downregulated | miR-205 | ↓ |
|
| Schubert et al. (2013) [62] | BCR tissues and disease-free tissues | Biochemical recurrence | 2 downregulated | let-7b and let-7c | ↓ |
|
| Leite et al. (2011) [66] | 21 frozen BCR tissues
28 frozen disease-free tissues | Biochemical recurrence | 4 upregulated | miR-100 | ↑ |
|
| Karatas et al. (2014) [72] | 82 PCa tissues
(41 BCR and 41 disease-free) | Biochemical recurrence | 3 downregulated | miR-1, miR-133b | ↓ |
|
| Selth et al. (2013) [102] | Serum samples from PCa patients (BCR = 8)
disease-free = 8) | Biochemical recurrence | 3 upregulated | miR-194 miR-146-3p | ↑ |
|
| Shen et al. (2012) [87] | Plasma samples from PCa () | Castration resistance | 2 upregulated | miR-21, miR-145 | ↑ |
|
|
Jalava et al. (2012) [90] | 28 primary PCa tissues
14 CRPC tissues
12 BPH tissues | Castration resistance | 4 upregulated
3 downregulated | miR-32, miR-148a,
miR-590-5p, miR-21 | ↑ |
miR-99a, miR-99b,
miR-221 | ↓ |
|
| Peng et al. (2011) [94] | 6 primary PCa tissues
7 bone metastatic tissues | Metastasis | 5 downregulated | miR-508-5p, miR-143,
miR-145, miR-33a,
miR-100 | ↓ |
|
| Saini et al. (2011) [95] | 36 PCa tissues
8 metastatic tissues
8 normal tissues | Metastasis | 1 downregulated | miR-203 | ↓ |
|
| Mitchell et al. (2008) [19] | Serum samples from metastatic PCa () and age-matched HD () | Metastasis | 6 deregulated | miR-141 | ↑ |
|
| Brase et al. (2011) [100] | Serum samples from localized PCa () and metastatic PCa () | Metastasis | 5 upregulated | miR-141, miR-375 | ↑ |
|
| Bryant et al. (2012) [48] | Serum samples from PCa () and metastatic PCa ()
Plasma samples from PCa () and metastatic PCa () | Metastasis | 2 upregulated | miR-141 and miR-375 | ↑ |
|
|
Nguyen et al. (2013) [103] |
Serum samples from localized PCa () and metastatic CRPC () | Castration resistance | 3 upregulated
1 downregulated | miR-141, miR-375,
miR-378* | ↑ |
| miR-409-3p | ↓ |
|
| Zhang et al. (2011) [88] | Serum samples from localized PCa (), ADPC (), CRPC DTX treated () and BPH () | Castration resistance | 1 upregulated | miR-21 | ↑ |
|
