Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis: A Case-Control Study in a Chinese Han Population

Table 2

Genotype and allele frequencies of rs2234693 and rs9340799 of the ESR1 gene in the Han Chinese population.

Group	Number	rs2234693							rs9340799
		Genotype (frequency)			Allele (frequency)		H-WE	Number	Genotype (frequency)			Allele (frequency)		H-WE
		TT	TC	CC	T	C	𝑃		AA	AG	GG	A	G	𝑃
OA
All	469	167 (0.356)	217 (0.463)	85 (0.181)	551 (0.587)	387 (0.413)	0.325	469	288 (0.614)	152 (0.324)	29 (0.062)	728 (0.776)	210 (0.224)	0.144
Female	356	119 (0.334)	170 (0.478)	67 (0.188)	408 (0.573)	304 (0.427)	0.649	356	210 (0.590)	122 (0.343)	24 (0.067)	542 (0.761)	170 (0.239)	0.280
Male	113	48 (0.425)	47 (0.416)	18 (0.159)	143 (0.633)	83 (0.367)	0.264	113	77 (0.682)	30 (0.265)	6 (0.053)	184 (0.814)	42 (0.186)	0.192
Control
All	514	198 (0.385)	242 (0.471)	74 (0.144)	638 (0.621)	390 (0.379)	0.997	522	348 (0.667)	155 (0.297)	19 (0.036)	851 (0.815)	193 (0.185)	0.736
Female	120	47 (0.392)	61 (0.508)	12 (0.100)	155 (0.646)	85 (0.0354)	0.223	124	82 (0.661)	40 (0.323)	2 (0.016)	204 (0.823)	44 (0.177)	0.242
Male	394	151 (0.383)	181 (0.459)	62 (0.158)	483 (0.613)	305 (0.387)	0.528	398	266 (0.668)	115 (0.289)	17 (0.043)	647 (0.813)	149 (0.187)	0.314

No.: number; H-WE: Hardy-Weinberg Equilibrium.