Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis: A Case-Control Study in a Chinese Han Population

Table 5

Association of the rs9340799 with knee OA in the Chinese Han population with a stratification by gender.

Groups compared	AA versuss AG + GG			AA + AG versus GG			A allele versus G allele			All genotyped*
	OR	95% CI	𝑃 value	OR	95% CI	𝑃 value	OR	95% CI	𝑃 value	𝑃 value
All patients (𝑛=469) versus all controls (𝑛=522)	1.257	0.969–1.630	0.085	1.745	0.965–3.156	0.063	1.272	1.022–1.583	0.031	0.084
Female patients (𝑛=356) and female controls (𝑛=124)	1.357	0.885–2.082	0.161	4.410	1.027–18.938	0.030	1.454	1.006–2.102	0.046	0.069
Male patients (𝑛=113) and male controls (398)	0.801	0.510–1.256	0.332	1.125	0.433–2.925	0.809	0.869	0.594–1.271	0.468	0.817

OR: Odds Ratio; CI: confidence interval.
∗AA, AG, and GG genotypes were grouped together and a 2×3 contingency-table analysis was performed.