Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis: A Case-Control Study in a Chinese Han Population

Table 7

Association of the rs9340799 with knee OA in the Chinese Han population with stratification by the severity of OA.

Groups compared	AA versus AG + GG			AA + AG versus GG			A allele versus G allele			All genotype*
	OR	95% CI	𝑃 value	OR	95% CI	𝑃 value	OR	95% CI	𝑃 value	𝑃 value
Mild OA (255 patients versus 522 controls)	1.269	0.930–1.732	0.132	2.011	1.036–3.902	0.036	1.312	1.013–1.701	0.039	0.073
Severe OA (214 patients versus 522 controls)	1.267	0.911–1.762	0.159	1.573	0.750–3.299	0.227	1.258	0.954–1.658	0.103	0.261

OR: Odds Ratio; CI: confidence interval.
∗AA, AG, and GG genotypes were grouped together and a 2×3 contingency-table analysis was performed.