Bimodal Imaging Probes for Combined PET and OI: Recent Developments and Future Directions for Hybrid Agent Development

Figure 1

Schematic depiction of the operation principle of a PET/OI hybrid compound. After being applied to the patient in a single injection, an initial whole-body PET scan is performed, identifying and localizing tumor and potential metastases, thus serving as a tool for surgery planning. During the following surgical intervention, the same compound—having accumulated in the target tumor areas over time—can be used as a marker for intraoperative image-guided surgery of the respective malignant tissues.