Bimodal Imaging Probes for Combined PET and OI: Recent Developments and Future Directions for Hybrid Agent Development

Figure 6

Schematic representation of different kinds of labeled nanoparticles that were already used as hybrid compounds for PET and OI: (a) coated quantum dot loaded with chelating agent for radiometal introduction, (b) coated iron oxide particle with encapsulated fluorescent dye and derivatized on its surface with a chelator for radiolabeling, (c) coated iron oxide particle derivatized on the surface with fluorescent dye and chelator for radiometal labeling, (d) silica nanoparticles with encapsulated fluorescent dye and surficial derivatization with radionuclide and targeting vector, and (e) coated quantum dot loaded with chelating agent for radiometal introduction and a targeting vector.