Challenges for Nerve Repair Using Chitosan-Siloxane Hybrid Porous Scaffolds

Table 1

Histomorphometrical assessment of the regenerated rat sciatic nerve wrapped with the solid or porous membranes during a healing period of 12 weeks after axonotmetic injury.

Group	Density (N/mm^2)	Number (N)	Fiber diameter (mm)	Axon diameter (mm)	Myelin thickness (mm)
Control	10,123 ± 8,340	7,621 ± 198	8.27 ± 0.29	5.34 ± 0.23	1.21 ± 0.05
Crush	18,452 ± 1,952	10,180 ± 964	5.31 ± 0.34	4.12 ± 0.32	0.60 ± 0.08
Solid membrane	17,196 ± 3,364	9,774 ± 359	5.77 ± 0.45	4.54 ± 0.35	0.62 ± 0.06
Porous membrane	14,210 ± 1,600	7,780 ± 1,053	6.72 ± 0.26	5.00 ± 0.19	0.86 ± 0.05
NEUROLAC (commercial PLGA nerve guided tube) [31]	21,982 ± 1,927	10,532 ± 2,195	3.49 ± 0.11	—	0.40 ± 0.02