Review Article

Challenges for Nerve Repair Using Chitosan-Siloxane Hybrid Porous Scaffolds

Table 2

Histomorphometrical assessment of the regenerated rat sciatic nerve, treated with hMSCs and porous membranes, during a healing period of 12 weeks after axonotmetic injury.

GroupDensity (N/mm2)Number (N)Fiber diameter (mm)Axon diameter (mm)Myelin thickness (mm)

CrushCell20,200 ± 4,9719,806 ± 2,6955.31 ± 0.193.74 ± 0.490.78 ± 0.10
CrushChCell21,514 ± 6,30811,413 ± 3,7524.90 ± 0.973.41 ± 0.720.75 ± 0.14
CrushCh15,533 ± 7,7137,982 ± 3,0925.29 ± 1.053.50 ± 0.551.02 ± 0.22
Control15,905 ± 2877,666 ± 1906.66 ± 0.124.26 ± 0.071.19 ± 0.03