Involvement of DNA Damage Response Pathways in Hepatocellular Carcinoma
Table 3
Summary of the involvement of the DDR pathways in potential therapy resistance in HCC.
Protein
DNA repair pathway
Underlying effects
Reference
Chk-1
HR
Shh ligand abolished RT-induced phosphorylation of Chk-1 as well as impairing the repair of DNA DSB, which results in HCC cells, HA22T, and Sk-Hep1, resistant to radiotherapy.
UCN-01 promotes the cytotoxicity of paclitaxel in paclitaxel resistant HCC cells (SNU449, SNU398, SUN368, SNU354, and HepG2 cells) via inhibiting activity of Chk-2.