New Biomarkers to Predict the Evolution of In Situ Breast Cancers

Table 1

Expression of different markers in tumor cells and stroma in relation to lesion grade (G).

Markers	Overall series; n = 44; (median, range)	G1 + G2; n = 23; (median, range)	G3; n = 21; (median, range)
TG2
Tumor cells	10 (0–100)	20 (0–100)	3 (0–80)	0.195
Stroma	100 (0–100)	100 (20–100)	100 (0–100)	0.874
	P < 0.0001**	P < 0.0001**	P < 0.0001**
HJURP
Tumor cells	3.5 (0–100)	3 (0–100)	4 (0–80)	0.582
Stroma	0 (0–80)	0 (0–80)	0 (0–70)	0.765
	P = 0.006**	P = 0.065**	P = 0.027**
HIF-1α
Tumor cells	0 (0–70)	0 (0–10)	3 (0–70)	0.001
Stroma	0 (0–10)	0 (0–10)	0 (0–10)	0.732
	P = 0.231**	P = 0.172**	P = 0.013**

values refer to the difference between tumor cell and stroma marker expression in G1 and G2 with respect to G3 lesions.
values refer to the difference between tumor cell and stroma marker expression within the same tumor grade and in the overall series.