New Biomarkers to Predict the Evolution of In Situ Breast Cancers

Table 4

Area under the curve (AUC) of single and combined markers in tumor and stromal cells.

Markers	Tumor cells; AUC (95% CI)		Stroma; AUC (95% CI)
TG2	0.60 (0.40–0.81)	—	0.56 (0.44–0.68)	—
HJURP	0.56 (0.34–0.78)	—	0.58 (0.39–0.77)	—
HIF-1α	0.63 (0.45–0.81)	—	0.63 (0.45–0.81)	—
TG2 + HJURP	0.62 (0.41–0.82)	0.202	0.65 (0.49–0.82)	0.060
TG2 + HIF-1α	0.65 (0.45–0.85)	0.682	0.68 (0.49–0.86)	0.396
HIF-1α + HJURP	0.72 (0.55–0.90)	0.317	0.80 (0.63–0.97)	0.071
HIF-1α + TG2 + HJURP	0.73 (0.57–0.90)	0.689	0.84 (0.70–0.98)	0.175