Review Article
Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer’s Disease
Table 2
Neuronal receptors impacted by A
o [
19,
175] and possible effects on downstream signalling pathways.
| | Receptor | Signal transduction pathway | References* |
| | NMDAR (NR2B subtype) | Erk1/2, CamKIV | [95, 176–182] | | mGluR5 (with PrPC) | PKC, MAPKs (Erk1/2, p38, and JNK) | [79] | | nAchR (7 subtype) | Erk1/2, Akt, and JAK-STAT | [183, 184] | | Wnt receptor | Wnt signalling (GSK3) | [185, 186] | | IR/IGF | PI3K-Akt | [176, 187] | | Amylin receptor | Erk1/2, PKA | [177] | | RAGE | p38 | [188] | | Neurotrophin receptors | Erk1/2, Akt | [45, 189] | | 2AR | PKA, Erk1/2, and JNK | [149, 190, 191] |
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*Including reviews with original research papers cited.
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