Review Article
Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer’s Disease
Table 3
Binding partners of TAU (modified from [
4,
192]).
| Binding partner | Region of TAU involved | Function/identity of binding partner | References |
| -tubulin | Repeat domains | Cytoskeleton | [193] | F-actin | | Cytoskeleton | [194] | ApoE3 | Repeat domains | Lipid carrier | [195, 196] | Fgr | Proline-rich domain | Src kinase family | [89] | Fyn | Proline-rich domain | Src kinase family | [82, 89] | Lck | Proline-rich domain | Src kinase family | [82, 89] | cSrc | Proline-rich domain | Src kinase family | [82, 89] | Grb2 | Proline-rich domain | Growth factor signalling | [89] | c-Abl | | Src kinase family | [197] | p85 | Proline-rich domain | Regulator PI3K, phospholipid signalling | [89] | PLCγ | | Phospholipid signalling | [89, 198] | GSK3 | N-terminal | Kinase | [199] | Calmodulin | Repeat domain |
Ca2+ signalling | [200, 201] | 14-3-3 | Proline-rich domain and repeat domain | Signalling scaffold | [202–204] | Annexin A2 | | Ca2+ signalling, membrane trafficking | [205] | Pin1 | Proline-rich domain | Peptidyl-prolyl cis/trans isomerase regulates phosphorylation of TAU | [206, 207] |
|
|