The Association Study of Calmodulin 1 Gene Polymorphisms with Susceptibility to Adolescent Idiopathic Scoliosis
Table 3
Association analysis of genotype distribution of 12 SNPs.
SNP loci
Major/minor allele
Location
Case group
Control group
value ()
ORc (95% CI)d
1/1
1/2
2/2
1/1
1/2
2/2
Genotypea
Alleleb
SNP01
C/A
Intron 1
1 (1%)
35 (24%)
110 (75%)
7 (5%)
47 (32%)
92 (63%)
0.0196
0.0079
0.5495 (0.3519–0.8579)
SNP02
G/C
Intron 1
1 (1%)
35 (24%)
110 (75%)
7 (5%)
47 (32%)
92 (63%)
0.0196
0.0079
0.5495 (0.3519–0.8579)
SNP03
T/C
Intron 1
11 (8%)
59 (41%)
75 (52%)
12 (8%)
50 (34%)
84 (58%)
0.5240
0.4800
1.1417 (0.7903–1.6494)
SNP04
G/A
Intron 3
6 (4%)
59 (40%)
81 (55%)
6 (4%)
51 (35%)
89 (61%)
0.6193
0.4311
1.1678 (0.7936–1.7184)
SNP05
C/T
Intron 3
103 (71%)
42 (29%)
1 (1%)
88 (60%)
51 (35%)
7 (5%)
0.0378
0.0257
1.6139 (1.0574–2.4634)
SNP06
A/C
Exon 6
122 (84%)
23 (16%)
1 (1%)
122 (84%)
24 (16%)
0 (0%)
0.6001
0.8814
1.0456 (0.5824–1.8771)
SNP07
C/T
Exon 6
107 (73%)
35 (24%)
4 (3%)
103 (71%)
42 (29%)
1 (1%)
0.2847
0.9075
1.0274 (0.6514–1.6203)
SNP 08
C/G
5′near gene
80 (55%)
58 (40%)
8 (5%)
85 (58%)
52 (36%)
9 (6%)
0.7643
0.7010
0.9289 (0.6375–1.3535)
SNP09
C/G
Exon 6
100 (68%)
42 (29%)
4 (3%)
102 (70%)
41 (28%)
3 (2%)
0.9164
0.7387
0.9285 (0.6004–1.4359)
SNP10
C/G
Exon 6
102 (70%)
41 (28%)
3 (2%)
93 (64%)
45 (31%)
8 (5%)
0.2376
0.1357
1.3765 (0.9038–2.0966)
SNP11
C/T
Intron 1
80 (56%)
58 (40%)
6 (4%)
89 (61%)
51 (35%)
6 (4%)
0.6328
0.4342
0.8568 (0.5815–1.2624)
SNP12
C/G
Intron 1
23 (16%)
71 (49%)
51 (35%)
34 (23%)
67 (46%)
45 (31%)
0.2711
0.1517
0.7865 (0.5662–1.0925)
values were calculated using the Cochran-Armitage trend test. values were calculated using the test.
cAllelic odds ratio.
dConfidence interval (CI). values were adjusted using the Bonferroni method for multiple tests. The bold font means .