Research Article

The Association Study of Calmodulin 1 Gene Polymorphisms with Susceptibility to Adolescent Idiopathic Scoliosis

Table 3

Association analysis of genotype distribution of 12 SNPs.

SNP lociMajor/minor alleleLocationCase groupControl group value ( )ORc (95% CI)d
1/11/22/21/11/22/2GenotypeaAlleleb

SNP01C/AIntron 11 (1%)35 (24%)110 (75%)7 (5%)47 (32%)92 (63%)0.01960.00790.5495  (0.35190.8579)
SNP02G/CIntron 11 (1%)35 (24%)110 (75%)7 (5%)47 (32%)92 (63%)0.01960.00790.5495  (0.35190.8579)
SNP03T/CIntron 111 (8%)59 (41%)75 (52%)12 (8%)50 (34%)84 (58%)0.52400.48001.1417 (0.7903–1.6494)
SNP04G/AIntron 36 (4%)59 (40%)81 (55%)6 (4%)51 (35%)89 (61%)0.61930.43111.1678 (0.7936–1.7184)
SNP05C/TIntron 3103 (71%)42 (29%)1 (1%)88 (60%)51 (35%)7 (5%)0.03780.02571.6139  (1.05742.4634)
SNP06A/CExon 6122 (84%)23 (16%)1 (1%)122 (84%)24 (16%)0 (0%)0.60010.88141.0456 (0.5824–1.8771)
SNP07C/TExon 6107 (73%)35 (24%)4 (3%)103 (71%)42 (29%)1 (1%)0.28470.90751.0274 (0.6514–1.6203)
SNP 08C/G5′near gene80 (55%)58 (40%)8 (5%)85 (58%)52 (36%)9 (6%)0.76430.70100.9289 (0.6375–1.3535)
SNP09C/GExon 6100 (68%)42 (29%)4 (3%)102 (70%)41 (28%)3 (2%)0.91640.73870.9285 (0.6004–1.4359)
SNP10C/GExon 6102 (70%)41 (28%)3 (2%)93 (64%)45 (31%)8 (5%)0.23760.13571.3765 (0.9038–2.0966)
SNP11C/TIntron 180 (56%)58 (40%)6 (4%)89 (61%)51 (35%)6 (4%)0.63280.43420.8568 (0.5815–1.2624)
SNP12C/GIntron 123 (16%)71 (49%)51 (35%)34 (23%)67 (46%)45 (31%)0.27110.15170.7865 (0.5662–1.0925)

values were calculated using the Cochran-Armitage trend test.
values were calculated using the test.
cAllelic odds ratio.
dConfidence interval (CI).
values were adjusted using the Bonferroni method for multiple tests.
The bold font means .