Research Article
Pathway-Driven Discovery of Rare Mutational Impact on Cancer
(1) In the given pathway, define a “gene list” | (2) gene list: gene names in the given pathway | (3) | (4) for each gene in the “gene list” ( in 1 ~ size of gene list) | (5) “candidate list” = “gene list” − gene[] | (6) while (no more genes in the “candidate list” or | (7) no more significant mutational event) { | (8) | (9) update: gene(s) name(s) to be considered as mutational event | (11) : a vector containing pathway statistics of patients with mutational event | (12) : a vector containing pathway statistics of patients without mutational event | (13) | (14) do t-test on and | (15) if (-test -value threshold) { | (16) add one more gene for mutational event | (17) } | (18) update the number of total iteration (this is used for -value calculation) | (19) remove the gene from the “candidate list” | (20) } | (21) } |
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