Pathway-Driven Discovery of Rare Mutational Impact on Cancer

Table 2

List of multi-gene mutational events with pathway level expression change.

Pathway	Mutational event; (# of distinct genes: 32)	# event sample	𝑡-stat	𝑞-value
KEGG_GLIOMA	PIK3CB, HRAS	5	12.587	0.000
KEGG_MELANOMA	PIK3CB, BRAF	7	10.302	0.000
PID_CDC42	CDH1, MAP3K1	70	−5.244	0.000
PID_TRAIL	RIPK1, MAPK3	6	9.624	0.000
BIOCARTA_PPARA	NCOR1, EHHADH	21	−4.562	0.007
PID_A6B1_A6B4_INTEGRIN	COL17A1, GRB2	6	−6.239	0.009
BIOCARTA_MTOR	TSC1, TSC2	7	−5.081	0.010
SIG_PIP3_SIGNALLING_IN_B_LYMPHOCYTES	ITPR3, RPS6KA3	7	6.174	0.014
PID_CERAMIDE	MAP2K4, AKT1, RIPK1	35	4.803	0.017
SA_PTEN	AKT3, BPNT1	5	−6.573	0.018
ST_FAS_SIGNALLING	MAP3K1, EZR	42	−3.727	0.029
PID_EPHBFWDPATHWAY	EPHB1, EFNB1	9	−4.848	0.032
KEGG_RENAL_CELL_CARCINOMA	EPAS1, GRB2, PDGFB	7	7.628	0.057
PID_ECADHERIN_KERATINOCYTE	CDH1, FMN1, PIP5K1A, EGFR, AKT2, CDH1, RAC1, CDH1, RAC1	49	−5.564	0.074
KEGG_BLADDER_CANCER	CDH1, THBS1, MDM2, RAF1	41	−4.966	0.083