Pathway-Driven Discovery of Rare Mutational Impact on Cancer

Table 3

List of multi-gene mutational events with pathway level expression change on drug target centric pathways.

Pathway	Mutational event	# event samples	𝑡-stat	𝑞-value
PDGFRB_neighbors	LYN, NCK1	5	−8.3139	0.005
FGFR2_neighbors	PIK3R1, PIK3CD, GRB2	18	3.506	0.141