p53 Is a Key Regulator for Osthole-Triggered Cancer Pathogenesis
Figure 3
Osthole increases p53 protein activation in human colon cancer. HCT116 (a) and SW480 (b) were incubated with osthole (10 μM) for indicated time periods. p53, phosphorylated p53 (p-p53), and acetylated p53 (acetyl-p53) expressions were examined by western blot analysis. (c) SW480 cells were stimulated by osthole for 6 h, and p53 and p21 expressions were examined by RT-PCR analysis. Results are the representative of three independent experiments.
