Evaluation of the Influence of Formulation and Process Variables on Mechanical Properties of Oral Mucoadhesive Films Using Multivariate Data Analysis
Table 1
Formulations of mucoadhesive films.
Sample
NaCMC
Glycerol
Textile
Water
Casted amount
A1
2%
1%
No
97%
18 mL
A2
2%
1.5%
No
96.5%
18 mL
A3
2%
2%
No
96%
18 mL
A4
2%
2.5%
No
95.5%
18 mL
A5
2%
3%
No
95%
18 mL
B1
2%
1%
No
97%
27 mL
B2
2%
1.5%
No
96.5%
27 mL
B3
2%
2%
No
96%
27 mL
B4
2%
2.5%
No
95.5%
27 mL
B5
2%
3%
No
95%
27 mL
C1
2%
1%
Yes
97%
up to 18 mL*
C2
2%
1.5%
Yes
96.5%
up to 18 mL*
C3
2%
2%
Yes
96%
up to 18 mL*
C4
2%
2.5%
Yes
95.5%
up to 18 mL*
C5
2%
3%
Yes
95%
up to 18 mL*
D1
2%
1%
Yes
97%
up to 27 mL*
D2
2%
1.5%
Yes
96.5%
up to 27 mL*
D3
2%
2%
Yes
96%
up to 27 mL*
D4
2%
2.5%
Yes
95.5%
up to 27 mL*
D5
2%
3%
Yes
95%
up to 27 mL*
The textile was impregnated with an amount of prepared dispersion to ensure the weight of resulting films corresponded to films prepared using the solvent casting method.