Evaluation of the Influence of Formulation and Process Variables on Mechanical Properties of Oral Mucoadhesive Films Using Multivariate Data Analysis

Table 1

Formulations of mucoadhesive films.

Sample	NaCMC	Glycerol	Textile	Water	Casted amount
A1	2%	1%	No	97%	18 mL
A2	2%	1.5%	No	96.5%	18 mL
A3	2%	2%	No	96%	18 mL
A4	2%	2.5%	No	95.5%	18 mL
A5	2%	3%	No	95%	18 mL
B1	2%	1%	No	97%	27 mL
B2	2%	1.5%	No	96.5%	27 mL
B3	2%	2%	No	96%	27 mL
B4	2%	2.5%	No	95.5%	27 mL
B5	2%	3%	No	95%	27 mL
C1	2%	1%	Yes	97%	up to 18 mL*
C2	2%	1.5%	Yes	96.5%	up to 18 mL*
C3	2%	2%	Yes	96%	up to 18 mL*
C4	2%	2.5%	Yes	95.5%	up to 18 mL*
C5	2%	3%	Yes	95%	up to 18 mL*
D1	2%	1%	Yes	97%	up to 27 mL*
D2	2%	1.5%	Yes	96.5%	up to 27 mL*
D3	2%	2%	Yes	96%	up to 27 mL*
D4	2%	2.5%	Yes	95.5%	up to 27 mL*
D5	2%	3%	Yes	95%	up to 27 mL*

∗The textile was impregnated with an amount of prepared dispersion to ensure the weight of resulting films corresponded to films prepared using the solvent casting method.