Evaluation of the Influence of Formulation and Process Variables on Mechanical Properties of Oral Mucoadhesive Films Using Multivariate Data Analysis

Table 2

Mechanical properties of mucoadhesive films.

Sample	Tensile testing			Puncture testing			Thickness; (mm)
	Strength*; (N)	Work*; (mJ)	Deformation*; (mm)	Strength*; (N)	Work*; (mJ)	Deformation*; (mm)
A1	26.55 ± 1.74	149.67 ± 31.31	9.18 ± 2.02	19.35 ± 0.86	22.55 ± 0.68	3.35 ± 0.07	83.76 ± 10.02
A2	18.54 ± 3.10	177.97 ± 29.62	14.27 ± 1.01	13.87 ± 1.08	20.20 ± 2.09	3.48 ± 0.11	101.69 ± 4.13
A3	14.07 ± 1.75	154.84 ± 24.40	19.77 ± 1.35	11.17 ± 2.31	23.29 ± 7.57	4.94 ± 0.71	109.90 ± 2.12
A4	7.43 ± 1.80	87.42 ± 11.11	35.56 ± 8.56	9.71 ± 2.89	34.64 ± 9.95	11.68 ± 0.36	83.84 ± 1.58
A5	4.06 ± 0.76	78.45 ± 22.73	35.78 ± 3.41	6.74 ± 0.95	24.53 ± 2.19	9.91 ± 0.34	112.05 ± 5.87
B1	20.77 ± 1.41	226.06 ± 11.19	6.50 ± 0.47	14.15 ± 1.79	18.33 ± 2.56	2.18 ± 0.20	145.70 ± 6.56
B2	15.86 ± 2.16	148.26 ± 42.46	12.04 ± 0.73	9.95 ± 1.38	21.39 ± 4.40	3.50 ± 0.22	156.18 ± 13.37
B3	5.94 ± 0.60	110.21 ± 11.47	21.02 ± 1.27	6.54 ± 1.36	21.57 ± 4.22	4.42 ± 0.07	205.13 ± 17.12
B4	5.83 ± 0.59	66.09 ± 1.83	24.71 ± 0.00	2.38 ± 0.30	12.05 ± 1.00	4.56 ± 0.17	250.85 ± 26.00
B5	0.82 ± 0.11	30.49 ± 4.56	20.89 ± 0.01	1.06 ± 0.11	6.97 ± 0.33	3.42 ± 0.14	296.64 ± 24.03
C1	10.45 ± 0.53	19.30 ± 5.16	0.96 ± 0.14	4.28 ± 0.45	3.35 ± 0.92	0.65 ± 0.08	268.17 ± 46.09
C2	7.69 ± 0.72	17.07 ± 3.32	1.22 ± 0.15	3.86 ± 0.52	4.28 ± 0.56	1.06 ± 0.03	221.46 ± 27.28
C3	5.29 ± 0.23	19.24 ± 3.85	1.18 ± 0.06	3.00 ± 0.12	3.75 ± 0.48	1.04 ± 0.04	246.93 ± 36.82
C4	4.59 ± 0.28	16.92 ± 4.28	1.41 ± 0.04	2.84 ± 0.41	3.93 ± 0.41	1.12 ± 0.07	217.33 ± 28.71
C5	3.39 ± 0.17	14.99 ± 1.69	1.10 ± 0.03	1.87 ± 0.25	3.09 ± 0.42	0.96 ± 0.04	257.23 ± 26.41
D1	17.96 ± 0.40	34.05 ± 2.33	1.22 ± 0.08	7.98 ± 0.59	5.74 ± 0.84	0.71 ± 0.05	220.00 ± 21.09
D2	12.07 ± 0.12	33.07 ± 2.86	1.31 ± 0.08	5.86 ± 0.57	5.68 ± 0.82	0.81 ± 0.06	266.97 ± 12.08
D3	7.65 ± 0.05	26.21 ± 6.85	1.30 ± 0.16	4.42 ± 0.56	4.82 ± 0.30	0.80 ± 0.07	302.97 ± 6.13
D4	4.36 ± 0.27	23.14 ± 4.04	1.25 ± 0.14	2.82 ± 0.55	4.20 ± 0.69	0.89 ± 0.09	315.90 ± 5.75
D5	3.71 ± 0.30	18.87 ± 4.92	1.13 ± 0.05	1.92 ± 0.12	2.97 ± 0.24	0.79 ± 0.11	322.70 ± 23.51

∗Recalculated for 100 𝜇m film thickness.