Unexpected Lack of Deleterious Effects of Uranium on Physiological Systems following a Chronic Oral Intake in Adult Rat
Figure 5
Effects of chronic uranium ingestion on immune cells in the intestinal mucosa in rats receiving contaminated drinking water during 9 months. Micrographs were obtained from control animals (objective ×20 and ×40). The brown staining indicates the cells positive for CD68 (macrophages) and for MPO (myeloperoxidase, neutrophils). Mast cells were stained with Alcian Blue technique. The positive cells were estimated per 5 villus-crypt axes, along the 60 measurements per animal, in control animals (NC: noncontaminated) and in animals contaminated with uranium (U) in their drinking water at various concentrations (0.2, 2, 20, or 120 mg/L). Data were mean ± SD of 8 rats. There is no significant difference between control and experimental groups.
