Unexpected Lack of Deleterious Effects of Uranium on Physiological Systems following a Chronic Oral Intake in Adult Rat

Figure 9

Effects of uranium on gene expression of enzymes of cholesterol metabolism in the liver. The gene expressions were measured in control animals (NC: noncontaminated) and in animals contaminated by uranium in their drinking water at various concentrations (0.2, 20, 40, and 120 mg/L). The mRNA levels are expressed as a ratio to the reference gene HPRT (hypoxanthine-guanine phophoribosyltransferase, a housekeeping gene). Data are mean ± SD of 8 animals. *𝑃<0.05, **𝑃<0.01: significantly different from control values.

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