A Promising Approach to Provide Appropriate Colon Target Drug Delivery Systems of Vancomycin HCL: Pharmaceutical and Microbiological Studies

Table 1

Composition of different vancomycin HCl matrix tablets prepared by direct compression.

Formulation code		Amount of ingredients in mg
	Drug	GG	XG	HPMC	HCO	EC	Eud. RL	Avicel	Mg. st : talc*
F0	100	—	—	—	—	—	—	195	5
F1	100	60	—	—	—	—	—	135	5
F2	100	90	—	—	—	—	—	105	5
F3	100	100	—	—	—	—	—	75	5
F4	100	120	—	—	—	—	—	45	5
F5	100	150	—	—	—	—	—	15	5
F6	100	180	—	—	—	—	—	95	5
F7	100	—	100	—	—	—	—	95	5
F8	100	50	50	—	—	—	—	95	5
F9	100	158	—	22	—	—	—	15	5
F10	100	136	—	44	—	—	—	15	5
F11	100	114	—	66	—	—	—	15	5
F12	100	90	—	90	—	—	—	15	5
F13	100	135	—	—	45	—	—	15	5
F14	100	105	—	—	75	—	—	15	5
F15	100	90	—	—	90	—	—	15	5
F16	100	135	—	—	—	45	—	15	5
F17	100	105	—	—	—	75	—	15	5
F18	100	90	—	—	—	90	—	15	5
F19	100	90	—	—	—	—	90	15	5
F20	100	135	—	—	—	—	45	15	5

∗Mixture of magnesium stearate (Mg. st) and talc in the ratio of 2 : 1 was used as a lubricant.