Drug Repositioning Discovery for Early- and Late-Stage Non-Small-Cell Lung Cancer

Table 5

Summary of the top ten pathways returned by REACTOME using CPDB for early- and late-stage NSCLC.

Early-stage NSCLC
Pathway name	Effective size	% of overlap	value
Cell surface interactions at the vascular wall	94	6.4%
Nephrin interactions	23	13%
Hemostasis	463	1.5%
Glycolysis	28	10.7%
Gluconeogenesis	32	9.4%
PECAM1 interactions	12	16.7%	0.00022
Integrin cell surface interactions	66	4.5%	0.00025
Glucose metabolism	67	4.5%	0.00026
Regulation of signaling by CBL	18	11.1%	0.00052
CD28 dependent PI3K/Akt signaling	21	9.5%	0.00071
Late-stage NSCLC
Pathway name	Effective size	% of overlap	value
Cell cycle	442	5.9%
Cell cycle, mitotic	355	6.8%
Mitotic M-M/G1 phases	214	8.4%
APC/C-mediated degradation of cell cycle proteins	38	26.3%
Regulation of mitotic cell cycle	38	26.3%
M phase	183	8.2%
Mitotic prometaphase	110	10.9%
Mitotic anaphase	130	9.2%
Mitotic metaphase and anaphase	131	9.2%
Resolution of sister chromatid cohesion	101	10.9%