Structural Insight into the DNA-Binding Mode of the Primosomal Proteins PriA, PriB, and DnaT
Figure 1
Two DnaB helicase-recruiting pathways for DNA replication restart at the stalled replication fork in vitro. The PriA-directed pathway (i.e., PriA-PriB-DnaT-DnaC-dependent reaction) preferentially uses fork structures without gaps in the leading strand, whereas the PriC-directed pathway (i.e., PriC-DnaC-dependent system) preferentially uses fork structures containing large gaps (>5 nucleotides) in the leading strand.
