Genetic Diversity and Distribution of Human Norovirus in China (1999–2011)

Figure 1

Genome map of norovirus (NoV; X86557). The NoV genome is composed of 3 open reading frames (ORFs). ORF1 (~5 kb) encodes the nonstructural proteins of an NTPase, 3C-like protease, and RNA-dependent RNA polymerase (RdRp). ORF2 is 1.8 kb in length and encodes the 57 kDa major structural capsid protein of viral protein 1 (VP1). VP1 is divided into the shell domain (S) and the protruding domain (P). The P domain contains two subdomains, known as P1 and P2. The regions of A, B, C, D, and E on NoV genome are used for genotyping. ORF3 encodes a minor structural protein VP2.