Bioassay Directed Isolation and Biological Evaluation of Compounds Isolated from Rubus fairholmianus Gard.

Figure 4

Close view of COX-1 docked with (a) indomethacin, (b) aspirin, (c) 1-(2-hydroxyphenyl)-4-methylpentan-1-one, and (d) 2-[(3-methylbutoxy)carbonyl]benzoic acid. Isolated compounds (green color ball stick mode) docked with target protein COX-1 (stick mode) through hydrogen bond interaction (pink color dot).