Long-Term Use of Probiotics Lactobacillus and Bifidobacterium Has a Prophylactic Effect on the Occurrence and Severity of Pouchitis: A Randomized Prospective Study

Table 1

Characteristics of the investigated group, pouchitis disease activity index (PDAI), and level of the pyruvate kinase (M2-PK) and calprotectin in the placebo and treatment group. Observation time—9 months, with asterisk (*) signing the data with statistically significant differences.

Patients	Placebo group before treatment	Placebo group after treatment	Probiotic group before treatment	Probiotic group after treatment
Number of patients	22	21	21	19
Number of patients with pouchitis (PDAI ≥ 7 pts)	7	8	7	3
Age of patients (years)	41.2	41.5	38.6	38.4
Time from operation (years)	9.2	9.1	8.9	8.9
PDAI	5.97	5.72	6.28*	4.43*
𝑃 value	𝑃=0.115861		𝑃=0.000342
M2-PK (U/mL)	87.4	90.1	92.3*	45.5*
𝑃 value	𝑃=0.877654		𝑃=0.000322
Calprotectin (mg/L)	57.5	55.8	65.8*	30.1*
𝑃 value	𝑃=0.107476		𝑃=0.000236