The Effects of Acute Hydrogen Sulfide Poisoning on Cytochrome P450 Isoforms Activity in Rats

Table 2

Precision, accuracy, recovery, and matrix effect of six probe drugs in rat plasma (mean ± SD, 𝑛=6).

Compound	Concentration (ng/mL)	Precision RSD (%)		Accuracy (%)		Recovery	Matrix effect
		Intraday	Interday	Intraday	Interday
Bupropion	20	6.7	9.1	102.6	102.8	83.4 ± 5.1	111.8 ± 4.7
	200	3.2	7.6	101.7	94.6	87.4 ± 4.9	101.2 ± 4.8
	1600	2.6	9.3	97.6	106.8	91.5 ± 4.7	96.4 ± 3.3
Metoprolol	20	13.3	13.4	104.5	94.8	84.9 ± 6.9	109.1 ± 4.7
	200	5.4	9.3	93.8	95.9	87.5 ± 5.8	106.3 ± 3.9
	1600	6.4	6.9	93.1	103.6	90.1 ± 4.4	97.2 ± 3.8
Midazolam	20	7	9.4	103.4	109.9	90.3 ± 7.5	104.3 ± 4.9
	200	6.6	5.9	92.3	88.7	92.1 ± 6.8	102.4 ± 5.5
	1600	2.6	6.5	96.2	106.3	94.2 ± 5.6	99.1 ± 4.8
Phenacetin	20	6.3	8.6	109.5	111.2	88.6 ± 5.7	88.2 ± 6.2
	200	11.6	10.2	105.7	96.3	86.6 ± 7.3	90.5 ± 6.8
	1600	3.4	7.6	97.8	105.2	92.6 ± 4.3	87.4 ± 4.2
Omeprazole	20	12.8	14.8	88.5	98.7	93.1 ± 9.2	86.7 ± 6.4
	200	5	7.7	91.7	104.5	88.7 ± 5.6	89.5 ± 4.7
	1600	4.9	8.6	94.5	105.1	90.2 ± 7.1	85.5 ± 6.7
Tolbutamide	20	11.4	13.5	91.8	103.4	89.1 ± 7.8	90.1 ± 4.8
	200	3.5	6	100.8	90.7	93.8 ± 5.6	87.5 ± 7.1
	1600	6.1	7.2	105.3	93.6	94.1 ± 4.7	85.3 ± 6.5