Research Article
The Effects of Acute Hydrogen Sulfide Poisoning on Cytochrome P450 Isoforms Activity in Rats
Table 2
Precision, accuracy, recovery, and matrix effect of six probe drugs in rat plasma (mean ± SD,
).
| Compound | Concentration (ng/mL) | Precision RSD (%) | Accuracy (%) | Recovery | Matrix effect | Intraday | Interday | Intraday | Interday |
| Bupropion | 20 | 6.7 | 9.1 | 102.6 | 102.8 | 83.4 ± 5.1 | 111.8 ± 4.7 | 200 | 3.2 | 7.6 | 101.7 | 94.6 | 87.4 ± 4.9 | 101.2 ± 4.8 | 1600 | 2.6 | 9.3 | 97.6 | 106.8 | 91.5 ± 4.7 | 96.4 ± 3.3 |
| Metoprolol | 20 | 13.3 | 13.4 | 104.5 | 94.8 | 84.9 ± 6.9 | 109.1 ± 4.7 | 200 | 5.4 | 9.3 | 93.8 | 95.9 | 87.5 ± 5.8 | 106.3 ± 3.9 | 1600 | 6.4 | 6.9 | 93.1 | 103.6 | 90.1 ± 4.4 | 97.2 ± 3.8 |
| Midazolam | 20 | 7 | 9.4 | 103.4 | 109.9 | 90.3 ± 7.5 | 104.3 ± 4.9 | 200 | 6.6 | 5.9 | 92.3 | 88.7 | 92.1 ± 6.8 | 102.4 ± 5.5 | 1600 | 2.6 | 6.5 | 96.2 | 106.3 | 94.2 ± 5.6 | 99.1 ± 4.8 |
| Phenacetin | 20 | 6.3 | 8.6 | 109.5 | 111.2 | 88.6 ± 5.7 | 88.2 ± 6.2 | 200 | 11.6 | 10.2 | 105.7 | 96.3 | 86.6 ± 7.3 | 90.5 ± 6.8 | 1600 | 3.4 | 7.6 | 97.8 | 105.2 | 92.6 ± 4.3 | 87.4 ± 4.2 |
| Omeprazole | 20 | 12.8 | 14.8 | 88.5 | 98.7 | 93.1 ± 9.2 | 86.7 ± 6.4 | 200 | 5 | 7.7 | 91.7 | 104.5 | 88.7 ± 5.6 | 89.5 ± 4.7 | 1600 | 4.9 | 8.6 | 94.5 | 105.1 | 90.2 ± 7.1 | 85.5 ± 6.7 |
| Tolbutamide | 20 | 11.4 | 13.5 | 91.8 | 103.4 | 89.1 ± 7.8 | 90.1 ± 4.8 | 200 | 3.5 | 6 | 100.8 | 90.7 | 93.8 ± 5.6 | 87.5 ± 7.1 | 1600 | 6.1 | 7.2 | 105.3 | 93.6 | 94.1 ± 4.7 | 85.3 ± 6.5 |
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